Evaluation of p16INK4a expression in ThinPrep cervical specimens with the CINtec p16INK4a assay
نویسندگان
چکیده
منابع مشابه
p16INK4A expression in cervical intraepithelial neoplasia and cervical cancer
Introduction: Cervical cancer is the third most common cancer among women and is more common in developing countries such as India, due to lack of good screening tests. The efficacy of the Pap smear is hampered by high inter-observer variability and high false positive and false negative rates. Liquid based cytology has not been shown to improve sensitivity or specificity when compared to Pap s...
متن کاملp16INK4a Expression in Porokeratosis
Vol. 29, No. 3, 2017 373 Received February 5, 2016, Revised May 16, 2016, Accepted for publication June 27, 2016 Corresponding author: Masutaka Furue, Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan. Tel: 81-92-642-5581, Fax: 81-92-642-5600, E-mail: [email protected] This is an Open Access arti...
متن کاملEvaluation of P16INK4A as a Biomarker in Cervical Intraepithelial Neoplasia
Introduction: Cervical screening would benefit from a test based on a disease-specific biomarker that identifies high grade lesions, which could also indicate the presence of early precancerous lesions that have a high risk of progression to cancer. One such potential biomarker is p16INK4A. Objective of the study was to study the biomarker p16INK4A expression by immunostaining in cervical intra...
متن کاملLiquid-based cytology--new possibilities in the diagnosis of cervical lesions.
Liquid-based cytology (LBC) enables the use of supplementary methods in the diagnosis and prognosis of cervical lesions. The aim of this study was to analyze the correlation between p16-INK4a immunoexpression in ThinPrep cervical cytologic samples and human papillomavirus (HPV) detection by polymerase chain reaction (PCR) from the same sample. LBC-ThinPrep (Cytyc, USA) cervical cytology samples...
متن کاملSignificance of immunohistochemical expression of p16INK4a in the differentiation of inflammatory and preneoplastic cervical lesions.
INTRODUCTION Most studies point at the main role of humanpapilloma virus (HPV) in the development of dysplasia and cervical cancer. Due to the low specificity and sensitivity of morphological diagnostic methods it is necessary to find an adequate marker which would be introduced in the screening program for cervical cancer. Most research suggests that p16INK4a is a specific and sensitive marker...
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ژورنال
عنوان ژورنال: Cancer
سال: 2007
ISSN: 0008-543X
DOI: 10.1002/cncr.22580